Mayo Clinic Anna-Maria and Stephen Kellen Building

Situated in Rochester’s Discovery Square, the Anna-Maria and Stephen Kellen Building represents a significant step in Mayo Clinic’s research evolution. Designed as a high-performance, future-ready biomedical facility, it anchors a dynamic ecosystem of life sciences, technology, and entrepreneurship. Integrated at street and subway levels, the building connects seamlessly to adjacent research infrastructure, supporting translational science and community engagement. 

A risk-zoned floorplate organizes wet, damp, and dry labs for optimized safety and energy efficiency, while a distinctive parametric metal scrim—drawn from Mayo’s three-shield logo—modulates daylight, reduces glare, and enhances performance. Inside, natural materials, unassigned workstations, and integrated technology cultivate a flexible, equitable, and wellness-focused research environment. All-electric systems, passive cooling, and layered ventilation cut energy use intensity by 40 percent compared with baseline. 

Through thoughtful design, engineering, and planning, the Anna-Maria and Stephen Kellen Building advances both the practice and culture of research, setting a new benchmark for sustainable, collaborative biomedical facilities.